The Houston Astros will face the Cleveland Guardians in a three-game MLB series starting on September 29. According to BetMGM, the Astros are favored to win the series (-135), while the Guardians have +115 odds. In the first game, the Astros are -155 favorites, with the Guardians at +135. The over/under for runs scored is set at 8.5. The second game features the Astros at -145 and the Guardians at +125, with an over/under of 8.5 runs. In the third game, the Astros are -145 favorites, and the Guardians have +125 odds. The over/under for runs scored is set at 8.5.