The Houston Astros and San Diego Padres face off in a three-game series starting Friday at Petco Park. The Astros are favored to win the series, with odds of -155. The Padres are underdogs at +135. In the first game, the Astros are -145 favorites, with the Padres at +135. The over/under for runs scored is 8.5. In the second game, the Astros are -135 favorites, with the Padres at +125. The over/under is 8.5 runs. In the third game, the Astros are -125 favorites, with the Padres at +115. The over/under is 8 runs.