Tue. Jun 24th, 2025

Houston Astros vs. San Diego Padres Prediction, Pick, Odds: Tuesday, September 17

The Houston Astros (85-66) visit Petco Park to take on the San Diego Padres (76-75) on Tuesday, September 17. The Astros have won three of their last five games, while the Padres have lost four of their last five. Houston’s Jose Altuve is hitting .344 in his last 10 games, while San Diego’s Manny Machado is hitting .357 in his last 10. The Astros are favored on the road, with the moneyline set at -155. The over/under is 8.5 runs.

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